dysphoria
noun/dɪsˈfɔriə/
Frequency rank: #19,110 most common English word
Meaning
A state of unease, dissatisfaction, or general unhappiness, often contrasted with euphoria.

Example sentence
After weeks of stress and poor sleep, she experienced intense dysphoria that made it hard to enjoy anything.
Synonyms & related words
- misery
- distress
- unhappiness
- despondency
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